王琦

博士 副教授，四川省特聘专家

王琦，新葡的京集团8814医学检验系副教授，硕士生导师，斯坦福大学访问学者，复旦大学博士。从事近红外一区、二区生物荧光探针及多肽药物研究。到目前为止，在Chemical Society Reviews, Chemical Science, Analytical Chemistry, Theranostics, Chemical Communications等杂志上共发表论文二十余篇，申请国家专利8项，授权4项，转化1项。担受邀任Analytical Chemistry, Chemical Science, Chemical Communications等期刊审稿人。近年来主持及参与国家自然科学基金各一项，参与科技部重大研究计划973项目一项，国家级大学生创新计划两项并获国家留学基金委资助于美国斯坦福大学研修。

一、研究方向

1、细胞代谢监测与成像新技术开发，细胞代谢调控机制研究，肿瘤及相关疾病（糖尿病、肥胖、心脑血管、神经疾病等）即时诊断试剂研发。

2、多肽药物方向：基于化学固相合成法合成具有新型结构及功能的抗菌、抗肿瘤多肽，利用超分子自组装实现多肽药物的性能改进。

二、代表论文

1. Yidan Zhu, Wenjun Jiang, Rui Chen, Jabrane Jouha, Qi Wang*, Li Wu*, Yuling Qin*, A post-pandemic perspective: Evolution of SARS-CoV-2 early detection, Trends in Analytical Chemistry, 2024, 170, 117458.

2. Majun Yang, Weida Zhu, Yilin Lv, Bin Jiang, Chenxia Jiang, Xiaobo Zhou, Guo Li, Yuling Qin, Qi Wang*, Ziwei Chen,* Li Wu,* A Dual-Responsive Ratiometric Indicator Designed for in Vivo Monitoring of Oxidative Stress and Antioxidant Capacity, Chemical Science, 2023, 14, 12961-12972 (Back cover, Nature Index).

3. Chaojie Yang, Chenxia Jiang, Majun Yang, Qingqing Bai, Yaya Zhen, Yuxue Zhang, Weiyi Yin, Jian Wang, Xiaobo Zhou, Guo Li, Mingmin Wu, Yuling Qin, Qi Wang*, Haiwei Ji*, and Li Wu*, NAD(P)H Activated Fluorescent Probe for Rapid Intraoperative Pathological Diagnosis and Tumor Histological Grading, Chemical & Biomedical Imaging, 2023, 1, 738-749 (Front cover, Editors' Choice)

4. Ke Zhang, Xiaobo Zhou,* Shijie Li, Lingfeng Zhao, Wenqi Hu, Aiting Cai, Yuhan Zeng, Qi Wang, Mingmin Wu, Guo Li, Jinxia Liu, Haiwei Ji, Yuling Qin,* Li Wu,* A General Strategy for Developing Ultrasensitive “Transistor-like” Thermochromic Fluorescent Materials for Multilevel Information Encryption, Advanced Materials, 2023, 2305472, DOI: 10.1002/adma.202305472.

5. Haiwei Ji, Xiaoxia Kang, Xiaoxiao Yang, Huanhuan Chen, Tianzhi Mao, Yue He, Jinxia Liu, Qi Wang, Xiaobo Zhou, Guo Li, Mingmin Wu, Hui Cong, Li Wu*, Yuling Qin*, Functionalized graphene-based electrochemical array sensors for the identification of distinct conformational states of Amyloid Beta in Alzheimer's disease, Biosensors and Bioelectronics, 2023, 222, 114927

6. Xiaobo Zhou, Yuhan Zeng, Shijie Li, Ke Zhang, Lingfeng Zhao, Guo Li, Qi Wang, Haiwei Ji, Mingmin Wu, Jinxia Liu, Yuling Qin, Wei Feng, Fuyou Li*, Li Wu*, Polymeric engineering of AIEgens for NIR-II fluorescence imaging and detection of abdominal metastases of ovarian cancer in vivo, Journal of Materials Chemistry B, 2023, 11 (47), 11217-11221

7. Haiwei Ji, Huanhuan Chen, Tianzhi Mao, Lingfeng Zhao, Ke Zhang, Majun Yang, Xiaobo Zhou, Qi Wang, Li Wu,* Yuling Qin,* Encryption-Decryption Strategy of High Security Constructed via Encoded Fluorescence Sensing and Linear Discriminant Analysis Technique, Advanced Optical Materials, 2023, 2300991, DOI: 10.1002/adom.202300991.

8. Guo Li, Mingmin Wu, Yongxiao Xu, Qi Wang, Jinxia Liu, Xiaobo Zhou, Haiwei Ji, Qu Tang,Xijuan Gu, Shujuan Liu, Yuling Qin*, Li Wu*, Qiang Zhao*. Recent progress in the development of singlet oxygen carriers for enhanced photodynamic therapy, Coordination Chemistry Reviews, 2023, 478, 214979.

9. Xiaobo Zhou, Lingfeng Zhao, Ke Zhang, Chaojie Yang, Shijie Li, Xiaoxia Kang, Guo Li, Qi Wang, Haiwei Ji, Mingmin Wu, Jinxia Liu, Yuling Qin*, Li Wu*, Ultrabright AIEdots with tunable narrow emission for multiplexed fluorescence imaging, Chemical Science, 2023, 14 (1), 113-120.

10. Jinxia Liu, Xiaodi Liu, Luxia Yang, Aiting Cai, Xiaobo Zhou*, Chu Zhou, Guo Li, Qi Wang, Mingmin Wu, Li Wu, Haiwei Ji*, Yuling Qin*, A highly sensitive electrochemical cytosensor based on a triple signal amplification strategy using both nanozyme and DNAzyme, Journal of Materials Chemistry B, 2022, 10, 700-706.

11. Qingqing Bai, Chaojie Yang, Majun Yang, Zhaoqing Pei, Xiaobo Zhou, Jinxia Liu, Haiwei Ji, Guo Li, Mingmin Wu, Yuling Qin, Qi Wang*, Li Wu*, pH-Dominated Selective Imaging of Lipid Droplets and Mitochondria via A Polarity-Reversible Ratiometric Fluorescent Probe, Analytical Chemistry, 2022, 94, 6, 2901-2911. (Cover figure, Nature Index)

12. Haiwei Ji, Haolu Hu, Qu Tang, Xiaoxia Kang, Xiaodi Liu, Lingfeng Zhao, Rongrong Jing, Mingmin Wu, Guo Li, Xiaobo Zhou, Jinxia Liu, Qi Wang, Hui Cong, Li Wu, Yuling Qin, Precisely Controlled and Deeply Penetrated Micro-Nano Hybrid Multifunctional Motors with Enhanced Antibacterial Activity against Refractory Biofilm Infections, Journal of Hazardous Materials, 2022, 436, 129210

13. Jinxia Liu, Xiaodi Liu, Huanhuan Chen, Luxia Yang, Aiting Cai, Haiwei Ji*, Qi Wang, Xiaobo Zhou, Guo Li, Mingmin Wu, Yuling Qin*, and Li Wu*, Bifunctional Pdots-Based Novel ECL Nanoprobe with Qualitative and Quantitative Dual Signal Amplification Characteristics for Trace Cytokine Analysis, Analytical Chemistry, 2022, 94 (19), 7115-7122.

14. Guo Li, Qi Wang, Jinxia Liu, Mingmin Wu, Haiwei Ji, Yuling Qin, Xiaobo Zhou and li wu, Innovative strategies for enhanced tumor photodynamic therapy, Journal of Materials Chemistry B, 2021, 9, 7347-7370.

15. Qi Wang, Jin Gong, Qingqing Bai, Yuling Qin, Xiaobo Zhou, Mingmin Wu,* Haiwei Ji,* Li Wu*, Hemoglobin Coated Oxygen Storagable Metal-organic Framework as A Promising Artificial Oxygen Carrier, Journal of Materials Chemistry B, 2021, 9 (19), 4002-4005. (Cover figure, hot paper)

16. Mingmin Wu, Mengtian Zhang, Zhiwei Fan, Xinyue Qin, Xiaoxia Zhu, Haiwei Ji, Yuling Qin, Qi Wang*, Li Wu*, Ultrasensitive DNA methyltransferase activity sensing and inhibitor evaluation with highly photostable upconversion nanoparticle transducer, Microchimica Acta, 2021, 188 (5), 1-9.

17. Xiaomin Zhu, Rongfeng Zou, Qi Wang*, Junchen Wu*, A supramolecular peptide polymer from hydrogen-bond and coordination-driven self-assembly, Polymer Chemistry, 2018, 9, 69-76.

18. Junchen Wu*, Qingchun Meng, Hongmei Ren, Hongtao Wang, and Jie Wu, Qi Wang*, Recent advances in peptide nucleic acid for cancer bionanotechnology, Acta Pharmacologica Sinica, 2017, 38, 798-805.

19. Yang Liu, Qi Wang, Pei She, Jin Gong, Weiping Wu, Shouming Xu, Jianguo Li, Kang Zhao, Anping Deng, Chitosan-coated hemoglobin microcapsules for use in an electrochemical sensor and as a carrier for oxygen, Microchimica Acta, 2016, 183 (11), 2847-2854.

20. Yang Liu, Jin Gong, Weiping Wu, Yuting Fang, Qi Wang, Haiying Gu, A novel bio-nanocomposite based on hemoglobin and carboxyl graphene for enhancing the ability of carrying oxygen, Sensors and Actuators B: Chemical, 2016, 222, 588-597.

21. Rongfeng Zou,# Qi Wang,# Jingxian Wu, Junchen Wu, Carsten Schmuck and He Tian, Peptide self-assembly triggered by metal ions, Chemical Society Reviews, 2015, 44, 5200-5219. (Co-first author, Nature Index)

22. Jingxian Wu, Rongfeng Zou, Qi Wang, Yajing Xue, Ping Wei, Shiping Yang, Junchen Wu* & He Tian*, A peptide probe for the detection of neurokinin-1 receptor by disaggregation enhanced fluorescence and magnetic resonance signals, Scientific Reports, 2014, 4, 6487.

23. Qi Wang,# Xiuyin Shi,# Xiaoxia Zhu, Martin Ehlers, Junchen Wu*, Carsten Schmuck*, A fluorescent light-up probe as an inhibitor of intracellular β-tryptase, Chemical Communications, 2014, 50, 6120-6122. (Co-first author, Nature Index)

24. Qi Wang, Lei Chen, Yitao Long, He Tian, Junchen Wu*, Molecular Beacons of Xeno-Nucleic Acid for Detecting Nucleic Acid, Theranostics, 2013, 3 (6), 395-408 (Cover figure).

25. Xiaoxia Zhu*, Qi Wang, Xiuyin Shi, Fengquan Liu, Liming Wang, Huiming Wang, Development and analytical validation of an Enzyme-Linked Immunosorbent Assay (ELISA) for the detection of copper in human hair and serum samples, Analytical Methods, 2013, 5 (10), 2578-2583.

26. Qi Wang, Chunyan Li, Ying Zou, Haoxuan Wang, Tao Yi*, Chunhui Huang, A highly selective fluorescence sensor for Tin (Sn4+) and its application in imaging live cells, Organic & Biomolecular Chemistry, 2012, 10 (33), 6740-6746.

27. Xudong Yu, Qian Liu, Junchen Wu, Mingming Zhang, Xinhua Cao, Song Zhang, Qi Wang, Liming Chen, Tao Yi*, Sonication-Triggered Instantaneous Gel-to-Gel Transformation, Chemistry-a European Journal, 2010, 16 (30), 9099-9106.

28. Qi Wang, Junchen Wu, Zuguang Gong, Ying Zou, Tao Yi*, Chunhui Huang, From vesicles to solid spheres: terminal functional group induced morphology modification, Soft Matter, 2010, 6 (12), 2679-2684.

三、专利

1. 王琦;朱晓霞;刘杨;弓瑾;吴伟平;鞠少卿;顾海鹰, 一种基于纳米粒子‑血红蛋白的人造血红细胞的制备方法, 中国，申请号：201710172238.6

2. 王琦;弓瑾;吴铭敏;朱晓霞;顾心亮;张颖，一种近红外二区方酸喹啉染料及其制备方法，中国，申请号：201910242205.3.

3. 王琦;吴铭敏;马振祥;范志伟;褚修余;龚莹，一种吲哚类过氧化氢荧光探针及其制备方法,中国，申请号：CN202010617384.7

4. 王琦;马振祥;吴铭敏;褚修余;赵其杰，一种喹啉类过氧化氢荧光探针及其制备方法,中国，申请号：CN202010617354.6

5. 王琦;马振祥;吴铭敏;龚莹;赵其杰，一种苯并吲哚类过氧化氢荧光探针及其制备方法，中国，申请号：CN202010796216.9

6. 王琦;白庆庆;杨超杰;杨马骏;吴丽;冀海伟;周晓波;李国;吴铭敏，一种pH敏感的比率型半花菁-罗丹明染料及其制备方法，中国，申请号: CN202111011513.9