李国
博士 校聘副教授
李国，博士研究生，副教授。2020年博士毕业于南京邮电大学获得生物电子学专业博士学位，师从国家杰青赵强教授。2020年9月加入新葡的京集团8814国家级人才团队，主要从事有机小分子和共轭聚合物的设计、合成及其在肿瘤诊疗中的应用研究。迄今为止，在Coord. Chem. Rev.、Research、Chem. Sci.、Anal. Chem.、Chem.Commun、ACS Appl. Mater. Interfaces、Nanophotonics in Biomedical Engineering等国际著名期刊上发表多篇学术论文和英文书稿。受邀担任PANS, Anal. Chem, ACS Appl. Mater. Interfaces, Chem. Commun等多个著名学术期刊审稿人。申请国家发明专利多项。主持国家自然科学基金青年项目一项，作为主要参与人参加国家级人才项目（青年）一项、国家自然科学基金面上项目一项、江苏省杰出青年基金项目一项。
主持或承担科研项目：
（1）国家自然科学基金青年基金，智能化级联响应聚合物光疗试剂用于非小细胞肺癌精准高效治疗，2022.01-2024.12，在研，主持；
（2）国家级人才项目（青年），肿瘤精准治疗需求牵引下的生物医学检验新技术研究，2022.01-2024.12，在研，骨干成员；
（3）国家自然科学基金面上项目，基于多色免疫组织化学的肿瘤免疫微环境分析新技术研究，2022.01-2025.12，在研，骨干成员；
（4）江苏省杰出青年基金项目，骨干成员。
（5）江苏特聘教授人才计划，骨干成员。
研究方向：
有机小分子：肿瘤微环境响应型有机小分子荧光探针的设计、合成及其在肿瘤检测和协同治疗中的应用研究。
共轭聚合物：构建可用于肿瘤检测和光动力光热协调治疗的共轭聚合物光疗试剂，利用共轭聚合物特殊性能开发其在细胞焦亡和免疫治疗中的应用。
代表学术论文:
(1) Guo Li‡, Liuwei Gu‡, Chaojie Yang‡, Xiaojie Kong, Yuling Qin* and Li Wu*, Lysosome-Anchoring Activation Design of Type I Photosensitizer Evokes Pyroptosis and Antitumor Immunity, ACS Mater. Lett., 2024, 6, 1820-1830.
(2) Liuwei Gu, Xiaojie Kong, Mengyan Li, Rui Chen, Ke Xu, Guo Li,* Yulin Qin* and Li Wu*, Molecule engineering strategy of toll-like receptor 7/8 agonists designed for potentiate immune stimuli activation, Chem. Commun., 2024, Advance Article.
(3) Guo Li, Mingmin Wu, Yongxiao Xu, Qi Wang, Jinxia Liu, Xiaobo Zhou, Haiwei Ji, Qu Tang, Xijuan Gu, Shujuan Liu, Yuling Qin,* Li Wu,* and Qiang Zhao*, Recent progress in the development of singlet oxygen carriers for enhanced photodynamic therapy, Coord. Chem. Rev., 2023, 478: 214979.
(4) Guo Li, Yongxiao Xu, Xiaojie Kong, Liuwei Gu, Yuling Qin,* and Li Wu,* NAD(P)H: quinone oxidoreductase 1 activatable toll-like receptor 7/8 agonist designed for precise immunotherapy, Chem. Commun., 2023, 59, 6343-6346.
(5) Liuwei Gu, Yinghao Li, Xiaojie Kong, Ke Zhang, Yuling Qin, Xiaobo Zhou*, Haiwei Ji*, Guo Li*, and Li Wu. A stable ratiometric fluorescent probe for hypochlorous acid detection and rheumatoid arthritis evaluation. Biomater. Sci., 2024, 12, 330.
(6) Jinxia Liu, Luxia Yang, Shijie Li, Ke Zhang, Xiaobo Zhou, Guo Li, Li Wu*, Yuling Qin*, Near-infrared electrochemiluminescence biosensors facilitated by thermally activated delayed fluorescence (TADF) emitters for ctDNA analysis, Biosensors and Bioelectronics, 2024, 251, 116103.
(7) Majun Yang, Weida Zhu, Yilin Lv, Bin Jiang, Chenxia Jiang, Xiaobo Zhou, Guo Li, Yuling Qin, Qi Wang,* Ziwei Chen,* Li Wu,* A Dual-Responsive Ratiometric Indicator Designed for in Vivo Monitoring of Oxidative Stress and Antioxidant Capacity, Chem. Sci., 2023, 14, 12961-12972.
(8) Ke Zhang, Xiaobo Zhou,* Shijie Li, Lingfeng Zhao, Wenqi Hu, Aiting Cai, Yuhan Zeng, Qi Wang, Mingmin Wu, Guo Li, Jinxia Liu, Haiwei Ji, Yuling Qin,* Li Wu,* A General Strategy for Developing Ultrasensitive “Transistor-like” Thermochromic Fluorescent Materials for Multilevel Information Encryption, Advanced Materials, 2023, 35, 2305472.
(9) Haiwei Ji, Xiaoxia Kang, Xiaoxiao Yang, Huanhuan Chen, Tianzhi Mao, Yue He, Jinxia Liu, Qi Wang, Xiaobo Zhou, Guo Li, Mingmin Wu, Hui Cong, Li Wu*, Yuling Qin*, Functionalized graphene-based electrochemical array sensors for the identification of distinct conformational states of Amyloid Beta in Alzheimer's disease, Biosensors and Bioelectronics, 2023, 222, 114927.
(10) Xiaobo Zhou, Yuhan Zeng, Shijie Li, Ke Zhang, Lingfeng Zhao, Guo Li, Qi Wang, Haiwei Ji, Mingmin Wu, Jinxia Liu, Yuling Qin, Wei Feng, Fuyou Li*, Li Wu*, Polymeric engineering of AIEgens for NIR-II fluorescence imaging and detection of abdominal metastases of ovarian cancer in vivo, Journal of Materials Chemistry B, 2023, 11 (47), 11217-11221.
(11) Chaojie Yang, Chenxia Jiang, Majun Yang, Qingqing Bai, Yaya Zhen, Yuxue Zhang, Weiyi Yin, Jian Wang, Xiaobo Zhou, Guo Li, Mingmin Wu, Yuling Qin, Qi Wang*, Haiwei Ji*, and Li Wu*, NAD(P)H Activated Fluorescent Probe for Rapid Intraoperative Pathological Diagnosis and Tumor Histological Grading, Chem. Biomed. Imaging, 2023, 1, 738-749.
(12) Xiaobo Zhou*, Lingfeng Zhao, Ke Zhang, Chaojie Yang, Shijie Li, Xiaoxia Kang, Guo Li, Qi Wang, Haiwei Ji, Mingmin Wu, Jinxia Liu, Yuling Qin* and Li Wu*, Ultrabright AIEdots with tunable narrow emission for multiplexed fluorescence imaging. Chem. Sci., 2023, 14, 113-120.
(13) Qingqing Bai, Chaojie Yang, Majun Yang, Zhaoqing Pei, Xiaobo Zhou, Jinxia Liu, Haiwei Ji, Guo Li, Mingmin Wu, Yuling Qin, Qi Wang*, and Li Wu*, pH-Dominated selective imaging of lipid droplets and mitochondria via a polarity-reversible ratiometric fluorescent probe. Anal. Chem. 2022, 94(6), 2901-2911.
(14) Jinxia Liu, Xiaodi Liu, Huanhuan Chen, Luxia Yang, Aiting Cai, Haiwei Ji*, Qi Wang, Xiaobo Zhou, Guo Li, Mingmin Wu, Yuling Qin* and Li Wu*, Bifunctional pdots-based novel ECL nanoprobe with qualitative and quantitative dual signal amplification characteristics for trace cytokine analysis. Anal. Chem. 2022, 94, 7115-7122.
(15) Linfeng Zhao, Can Zhao, Jiasheng Zhou , Yuling Qin, Guo Li*, Li Wu* and Xiaobo Zhou*, Conjugated polymers-based luminescent probes for ratiometric detection of biomolecules, J. Mater. Chem. B, 2022, 10, 7309-7327.
(16) Jinxia Liu, Xiaodi Liu, Luxia Yang, Aiting Cai, Xiaobo Zhou*, Chu Zhou, Guo Li, Qi Wang, Mingmin Wu, Li Wu, Haiwei Ji* and Yuling Qin*, A highly sensitive electrochemical cytosensor based on a triple signal amplification strategy using both nanozyme and DNAzyme, J. Mater. Chem. B, 2022, 10, 700-706.
(17) Guo Li, Qi Wang, Jinxia Liu, Mingmin Wu, Haiwei Ji, Yuling Qin*, Xiaobo Zhou* and Li Wu*, Innovative strategies for enhanced tumor photodynamic therapy, J. Mater. Chem. B, 2021, 9, 7347-7370.
(18) Guo Li, Xiangxiang Zhang, Weili Zhao, Weiwei Zhao, Feiyang Li, Kang Xiao, Qi Yu, Shujuan Liu*, and Qiang Zhao*, Stable and well-organized near-infrared (NIR) platinum(II)-acetylide metallacycles mediated cancer phototherapy, ACS Appl. Mater. Interfaces, 2020, 12, 20180-20190.
(19) Guo Li, Ruyi Zhou, Weili Zhao, Bo Yu, Jie Zhou, Shujuan Liu*, Wei Huang*, and Qiang Zhao*, Photothermally-responsive conjugated polymeric singlet oxygen carrier for phase-change-controlled and sustainable phototherapy for hypoxic tumor, Research, 2020, 5351848.
(20) Guo Li, Wenbo Hu, Menglong Zhao, Weili Zhao, Feiyang Li, Shujuan Liu*, Wei Huang, and Qiang Zhao*, Rational design of near-infrared platinum(II)-acetylide conjugated polymers for photoacoustic imaging-guided synergistic phototherapy under 808 nm irradiation, J. Mater. Chem. B, 2020, 8, 7356-7364.
(21) Xue Liu, Guo Li, Mingjuan Xie, Song Guo, Weili Zhao, Feiyang Li, Shujuan Liu*, and Qiang Zhao*, Rational design of type I photosensitizers based on Ru(II) complexes for effective photodynamic therapy under hypoxia, Dalton Trans., 2020, 49, 11192-11200.
(22) Guo Li, Tianci Huang, Mingjuan Xie, Xiangxiang Zhang, Qi Yu, Shujuan Liu*, Tianshe Yang, and Qiang Zhao*, A platinum(II)-acetylide-based conjugated polyelectrolyte for hypoxia imaging via ratiometric and time-resolved luminescence microscopy, J. Organomet. Chem, 2019, 879: 144-149.
(23) Guo Li, Tianshe Yang, Weiwei Zhao, Shujuan Liu, Wei Huang, Qiang Zhao*, Luminescent conjugated polymer dots for biomedical applications, Springer Book Frontiers of Nanophotonics in Biomedical Engineering. (chapter)
(24) Qi Yu, Tianci Huang, Chao Liu, Menglong Zhao, Mingjuan Xie, Guo Li, Shujuan Liu, Wei Huang* and Qiang Zhao*, Oxygen self-sufficient NIR-activatable liposomes for tumor hypoxia regulation and photodynamic therapy, Chem. Sci. 2019, 10, 9091-9098.
(25) Yunjian Xu, Teng Feng, Tianshe Yang, Huanjie Wei, Huiran Yang, Guo Li, Menglong Zhao, Shujuan Liu*, Wei Huang*, and Qiang Zhao*, Utilizing intramolecular photoinduced electron transfer to enhance photothermal tumor treatment of aza-BODIPY-based near-infrared nanoparticles, ACS Appl. Mater. Interfaces, 2018, 10, 16299-16307.
学术奖励和发明专利:
1. 李国 刺激响应型光学探针用于肿瘤光-免疫治疗, 中国微米纳米技术学会微纳传感技术与检测创新论坛（2023）, 厦门, 2023-11-18至2023-11-20 会议报告
2. 李国 刺激响应型光学探针用于肿瘤光-免疫治疗, 第十六届全国化学传感器学术会议（SCCS2023）, 济南, 2023-9-22至2023-9-24 会议报告
3. 江苏省研究生生物安全技术与促进创新实践大赛二等奖指导老师, 江苏省理学2类研究生教育指导委员会
4. 赵强 刘淑娟 李国 黄维 张享享，一种双发射共轭聚合物乏氧探针的制备及应用，中国，专利号：ZL201810174307.1。
2．赵强 刘淑娟 李国 黄维 张享享, 一种近红外共轭聚合物及其制备方法和应用，中国，专利号：ZL201810198193.4。